WEAK MALE-DRIVEN MOLECULAR EVOLUTION IN RODENTS
WEAK MALE-DRIVEN MOLECULAR EVOLUTION IN RODENTS
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DOI：
10.1073/pnas.91.2.827
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发表时间：
1994-01-18
影响因子：
11.1
通讯作者：
LI, WH
中科院分区：
文献类型：
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作者：
CHANG, BHJ;SHIMMIN, LC;LI, WH
在人类和啮齿类动物中，突变率（α（m））的男女比例被认为是非常大的，因此核苷酸取代的过程几乎完全是男性驱动的。然而，我们从X染色体连锁（Zfx）和Y染色体连锁（Zfy）锌指蛋白基因的最后一个内含子的序列数据表明，在啮齿动物中，α（m）仅近似于2，95%置信区间为1至3。此外，从已发表的关于卵子发生和精子发生的数据中，我们估计啮齿类动物每代生殖细胞分裂次数的男女比例约为2，证实了我们对α（m）的估计，并表明DNA复制错误是突变的主要来源。由于啮齿动物的估计阿尔法（m）仅为我们之前估计的高等灵长类动物约6的三分之一，因此似乎存在世代效应-即，α（m）随着生成时间的减少而减小。
In humans and rodents the male-to-female ratio of mutation rate (alpha(m)) has been suggested to be extremely large, so that the process of nucleotide substitution is almost completely male driven. However, our sequence data from the last intron of the X chromosome-linked (Zfx) and Y chromosome linked (Zfy) zinc finger protein genes suggest that alpha(m) is only approximate to 2 in rodents with a 95% confidence interval from 1 to 3. Moreover, from published data on oogenesis and spermatogenesis we estimate the male-to-female ratio of the number of germ cell divisions per generation to be approximate to 2 in rodents, confirming our estimate of alpha(m) and suggesting that errors in DNA replication are the primary source of mutation. As the estimated alpha(m) for rodents is only one-third of our previous estimate of approximate to 6 for higher primates, there appear to be generation-time effects-i.e., alpha(m) decreases with decreasing generation time.