CYCLIC ADENOSINE MONOPHOSPHATE PHOSPHODIESTERASE IN BRAIN - EFFECT ON ANXIETY
CYCLIC ADENOSINE MONOPHOSPHATE PHOSPHODIESTERASE IN BRAIN - EFFECT ON ANXIETY
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DOI：
10.1126/science.176.4033.428
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
HOROVITZ, ZP
中科院分区：
文献类型：
--
作者：
BEER, B;CHASIN, M;HOROVITZ, ZP
减少焦虑的药物可能是由大脑中的环磷酸腺苷介导的，因为（i）有效的减少焦虑的药物也是大脑磷酸二酯酶活性的有效抑制剂;（ii）二丁酰环磷酸腺苷具有减少焦虑的能力;（iii）甲基黄嘌呤显示出显著的减少焦虑的作用;（iv）茶碱和利氮卓产生附加的减少焦虑的活性;（iv）茶碱和利氮卓产生附加的减少焦虑的活性。和（v）在药物的减轻焦虑特性和它们抑制脑中磷酸二酯酶活性的能力之间存在显著的相关性。
Drugs that reduce anxiety may be mediated by cyclic adenosine monophosphate in the brain because (i) potent anxiety-reducing drugs are also potent inhibitors of brain phosphodiesterase activity; (ii) dibutyryl cyclic adenosine monophosphate has the ability to reduce anxiety; (iii) the methylxanthines show significant anxiety-reducing effects; (iv) theophylline and chlordiazepoxide produce additive anxiety-reducing activity; and (v) there is a significant correlation between the anxiety-reducing property of drugs and their ability to inhibit phosphodiesterase activity in the brain.