Incidence of SARS-CoV-2 over four epidemic waves in a low-resource community in Rio de Janeiro, Brazil: A prospective cohort study.
Incidence of SARS-CoV-2 over four epidemic waves in a low-resource community in Rio de Janeiro, Brazil: A prospective cohort study.
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DOI：
10.1016/j.lana.2022.100283
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发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
Brasil, Patricia
中科院分区：
文献类型：
--
作者：
Carvalho, Marilia Sa;Bastos, Leonardo Soares;Fuller, Trevon;Cruz, Owaldo Goncalves;Damasceno, Luana;Calvet, Guilherme;Resende, Paola Cristina;Smith, Chris;Whitworth, Jimmy;Siqueira, Marilda;Brasil, Patricia
低资源社区中SARS-CoV-2感染的发病率可以为疫苗接种战略和非药物干预措施(NPI)提供信息。我们的目标是估计里约热内卢贫民窟四次流行浪潮的发病率，该贫民窟是全球南部经济贫困地区的代表。通过聚合酶链式反应和血清学方法对儿童和家庭接触者进行SARS-CoV-2筛查的预期队列。将每一波-第一波、Zeta、Gamma和Delta-估计的PCR阳性感染的发病率密度与NPI和疫苗接种覆盖率相结合的指数进行比较。从2020年5月到2021年11月，共有718个家庭和2501个人参加。第一波SARS-CoV-2感染的发病密度是其他波的2.3倍。儿童的发病率低于年龄较大的参与者，但在后期，老年人的疫苗接种率达到90%。家庭集聚仅在第一波期间与发病率显著相关。感染的发生率大大超过了类似队列中报告的比率。在Delta变异波期间观察到的老年人发病率的下降，尽管NPI有所回落，但可以归因于疫苗覆盖率的增加。年轻人的高发病率加强了这一年龄段接种疫苗的重要性，这项政策尚未得到社会某些部门的充分支持。英国医学研究委员会、里约热内卢州科学促进基金会、国家科学和技术发展委员会。
Incidence rates of SARS-CoV-2 infections in low-resource communities can inform vaccination strategies and non-pharmaceutical interventions (NPIs). Our objective was to estimate incidence over four epidemic waves in a slum in Rio de Janeiro, a proxy for economically deprived areas in the Global South. Prospective cohort of children and household contacts screened for SARS-CoV-2 by PCR and serology (IgG). The incidence density of PCR positive infections estimated for each wave - the first wave, Zeta, Gamma and Delta - was compared to an index combining NPIs and vaccination coverage. 718 families and 2501 individuals were enrolled, from May 2020 to November 2021. The incidence density of SARS-CoV-2 infection due to the first wave was 2, 3 times that of the other waves. The incidence among children was lower than that of older participants, except in later waves, when vaccination of the elderly reached 90%. Household agglomeration was significantly associated with incidence only during the first wave. The incidence of infection greatly exceeded rates reported in similar cohorts. The observed reduction in incidence in the elderly during the Delta variant wave, in spite of the rollback of NPIs, can be attributed to increased vaccine coverage. The high incidence in young people reinforces the importance of vaccination in this age group, a policy that has yet to receive the full support of some sectors of society. UK Medical Research Council, Foundation for the Advancement of Science of the State of Rio de Janeiro, National Council for Scientific and Technological Development.
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影响因子：
8
作者：
Lugon P;Fuller T;Damasceno L;Calvet G;Resende PC;Matos AR;Machado Fumian T;Malta FC;Salgado AD;Fernandes FCM;Abreu de Carvalho LM;Guaraldo L;Bastos L;Cruz OG;Whitworth J;Smith C;Nielsen-Saines K;Siqueira M;Carvalho MS;Brasil P
通讯作者：
Brasil P
DOI：
10.1016/s2214-109x(21)00386-7
发表时间：
2021-11
期刊：
The Lancet. Global health
影响因子：
--
作者：
Gudina EK;Ali S;Girma E;Gize A;Tegene B;Hundie GB;Sime WT;Ambachew R;Gebreyohanns A;Bekele M;Bakuli A;Elsbernd K;Merkt S;Contento L;Hoelscher M;Hasenauer J;Wieser A;Kroidl A
通讯作者：
Kroidl A
影响因子：
8.4
作者：
de Aguiar, Daniele Fernandes;de Barros, Eliana Nogueira C.;de Noronha, Tatiana Guimaraes
通讯作者：
de Noronha, Tatiana Guimaraes
DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
11.8
作者：
Dawood, Fatimah S.;Varner, Michael;Stockwell, Melissa S.
通讯作者：
Stockwell, Melissa S.