Primordial germ cell migration
Primordial germ cell migration
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DOI：
10.1387/ijdb.041833km
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发表时间：
2004-01-01
影响因子：
0.7
通讯作者：
Wylie, C
中科院分区：
文献类型：
--
作者：
Molyneaux, K;Wylie, C
在果蝇和斑马鱼中的突变和反义筛选，以及在小鼠中的转录图谱和时间推移分析，对我们理解PGC的发育有很大的帮助。在所有这三个系统中，PGCs的行为都受生长因子的控制，这些生长因子通过G蛋白偶联受体和/或酪氨酸激酶受体传递信号。此外，调节细胞-细胞和细胞-底物的黏附对PGC的运动也很重要。最后，局部的生长因子可能控制PGC的存活，从而控制PGC的位置。趋化作用、调节的黏附和细胞存活对于发育和疾病期间发生的多个迁移过程是重要的。PGC迁移共享这些功能。
Mutational and antisense screens in Drosophila and zebrafish, and transcriptional profiling and time-lapse analysis in the mouse, have contributed greatly to our understanding of PGC development. In all three systems, the behavior of PGCs is controlled by growth factors which signal through G-protein coupled receptors and/or tyrosine kinase receptors. Additionally, regulated cell-cell and cell-substrate adhesion is important for PGC motility. Finally, localized growth factors may control PGC survival and consequently PGC position. Chemotaxis, regulated adhesion and cell survival are important for multiple migration processes which occur during development and disease. PGC migration shares these features.