Epigenetics and therapeutic targets mediating neuroprotection.
Epigenetics and therapeutic targets mediating neuroprotection.
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DOI：
10.1016/j.brainres.2015.07.034
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发表时间：
2015-12-02
期刊：
影响因子：
2.9
通讯作者：
Mehler MF
中科院分区：
文献类型：
--
作者：
Qureshi IA;Mehler MF
The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve as important mediators of the pathogenic processes that lead to irrevocable neural injury and of countervailing homeostatic and regenerative responses. Epigenetics is, therefore, of considerable translational significance to the field of neuroprotection. In this brief review, we provide an overview of epigenetic mechanisms and highlight the emerging roles played by epigenetic processes in neural cell dysfunction and death and in resultant neuroprotective responses.
