FIBROEPITHELIOMA OF PINKUS - ECCRINE DUCT SPREAD OF BASAL-CELL CARCINOMA
FIBROEPITHELIOMA OF PINKUS - ECCRINE DUCT SPREAD OF BASAL-CELL CARCINOMA
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DOI：
10.1097/00000372-199412000-00002
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发表时间：
1994-12-01
影响因子：
1.1
通讯作者：
SMITH, RRL
中科院分区：
文献类型：
--
作者：
STERN, JB;HAUPT, HM;SMITH, RRL
基底细胞癌（BCC）的扩散直接进入真皮或毛囊的两侧是一个常见的病理观察。BCC通过外分泌管传播，这已经得到较少的承认，是本次调查的主题。我们特别讨论的问题，是否小汗腺导管蔓延占的组织学模式的纤维上皮瘤的平库斯（feP）型BCC。25例基底细胞癌，包括12例足上皮癌，5例浅表基底细胞癌，6例普通基底细胞癌，1例足底基底细胞癌，1例伴有明显毛囊扩散的基底细胞癌，用H&E切片进行了研究; 11例进行了癌胚抗原免疫染色。在普通基底细胞癌中，偶见小汗腺导管嵌顿。一个浅表基底细胞癌包围近端部分的外分泌管。来自脚底的BCC显示出向外分泌管的晚期扩散;观察到导管上皮和管腔的局灶性闭塞，以及向固体BCC的链的过渡。12例feP中有9例显示一个或多个小汗腺导管病灶伴肿瘤链。这些研究结果表明，外分泌管作为初始模板feP，随后被BCC取代。然而，基底细胞癌的小汗腺导管扩散可能不一定会导致feP的组织学类型。
The spread of basal cell carcinoma (BCC) directly into the dermis or down the sides of hair follicles is a commonplace pathologic observation. BCC spread via eccrine ducts, which has received less recognition, is the subject of this investigation. We specifically address the question of whether eccrine duct spread accounts for the histologic pattern of the fibroepithelioma of Pinkus (feP) type of BCC. Twenty-five BCC, including 12 feP, five superficial BCC, six ordinary BCC, one BCC of the sole of the foot, and one BCC with prominent hair follicle spread were studied with H&E sections; 11 were immunostained for carcinoembryonic antigen. In ordinary BCC, occasional entrapped eccrine ducts were present. One superficial BCC surrounded the proximal portion of an eccrine duct. The BCC from the sole of the foot showed advanced spread down eccrine ducts; focal obliteration of duct epithelium and lumen was seen, as was transition to strands of solid BCC. Nine of the 12 feP showed one or several eccrine duct foci with tumor strands. These findings suggest that eccrine ducts serve as an initial template in feP and subsequently are replaced by the BCC. However, eccrine duct spread of BCC may occur without necessarily imparting an feP histologic pattern.