Plasma Lipids and Steroid Hormones in Patients with Hypercholesterolaemia or Hyperlipaemia during Dehydroepiandrosterone Sulphate Administration *
Plasma Lipids and Steroid Hormones in Patients with Hypercholesterolaemia or Hyperlipaemia during Dehydroepiandrosterone Sulphate Administration *
复制标题
硫酸脱氢表雄酮给药期间高胆固醇血症或高脂血症患者的血浆脂质和类固醇激素*
DOI：
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发表时间：
1972
影响因子：
5.5
通讯作者：
R. Vihko
中科院分区：
文献类型：
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作者：
H. Adlebcreutz;J. Kerstell;Kirk Schaumann;A. Svanborg;R. Vihko
抽象的。13例高胆固醇血症或高脂血症患者口服硫酸脱氢表雄酮20~80 mg。观察治疗前和治疗中血脂、中性类固醇硫酸盐水平，以及个体11-脱氧-17-酮类固醇和雌激素的排泄情况。没有观察到对血浆游离或酯化胆固醇、总磷脂值或个体磷脂值、或常规血液血液学或化学分析的影响。然而，血浆C19类固醇硫酸盐水平和尿中11-脱氧-17-酮类固醇排泄量显著增加，表明给药的化合物吸收良好。DHEA硫酸盐处理后，雌激素排泄量没有明显变化。13例男性高胆固醇、高脂血症患者与42例同龄正常对照组比较，尿脱氢表雄酮、雌酮及雌酮+雌二醇排泄率明显降低。
Abstract. DHEA sulphate was administered orally in doses of 20 to 80 mg to 13 subjects with hypercholesterolaemia or hyperlipaemia. Plasma lipid and neutral steroid sulphate levels as well as the excretion of individual ll‐deoxy‐17‐ketosteroids and estrogens in urine were investigated before and during the treatment. No effect was observed on plasma free or esterified cholesterol, on total or individual phospholipid values, or on routine blood haematological or chemical analyses. However, the plasma C19 steroid sulphate levels increased considerably as well as the urinary excretion of the 11‐deoxy‐17‐keto‐steroids, indicating good absorption of the compound administered. No significant changes in estrogen excretion following DHEA sulphate treatment could be noted. —When 13 male subjects with hypercholesterolaemia and hyperlipaemia were compared with 42 normal controls of the same mean age, a significantly lower urinary excretion of dehydroepiandrosterone and estrone as well as of estrone + estradiol was observed in the pathological series.