Mature and Juvenile Tissue Models of Regeneration in Small Fish Species
Mature and Juvenile Tissue Models of Regeneration in Small Fish Species
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DOI：
10.1086/bblv221n1p62
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发表时间：
2011-08
期刊：
影响因子：
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通讯作者：
Nozomi Yoshinari;A. Kawakami
中科院分区：
文献类型：
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作者：
Nozomi Yoshinari;A. Kawakami
构成生物体的众多细胞都很脆弱，日复一日地容易受损。因此，维持组织形态和功能是多细胞生物获得长寿的基础。为了正确维持组织完整性，生物体必须具有检测组织质量损失、激活细胞从头产生并将这些细胞组织成功能组织的机制。然而，人们对这些过程知之甚少。在这里，我们概述了斑马鱼和青鳉等小型鱼类的成体和幼体组织再生模型，并重点介绍了分子水平上的最新进展。从这些进展中，我们逐渐认识到，再生鱼鳍的表皮和间质部分（分别是伤口表皮和胚基）包含具有不同分子特性的异质细胞群，这些细胞可以被称为“区室”。这些区室及其相互相互作用被认为在促进组织再生的正常进展中发挥着重要作用。我们进一步描述了目前对这些区室的理解，并讨论了更好地理解它们在再生过程中的作用和相互作用的可能方法。
The multitude of cells constituting organisms are fragile and easily damaged day by day. Therefore, maintenance of tissue morphology and function is fundamental for multicellular organisms to attain long life. For proper maintenance of tissue integrity, organisms must have mechanisms that detect the loss of tissue mass, activate the de novo production of cells, and organize those cells into functional tissues. However, these processes are only poorly understood. Here we give an overview of adult and juvenile tissue regeneration models in small fish species, such as zebrafish and medaka, and highlight recent advances at the molecular level. From these advances, we have come to realize that the epidermal and mesenchymal parts of the regenerating fish fin—that is, the wound epidermis and blastema, respectively—comprise heterogeneous populations of cells with different molecular identities that can be termed “compartments.” These compartments and their mutual interactions are thought to play important roles in promoting the proper progression of tissue regeneration. We further describe the current understanding of these compartments and discuss the possible approaches to affording a better understanding of their roles and interactions during regeneration.