Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021
Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021
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DOI：
10.1093/infdis/jiab619
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发表时间：
2022-01-29
影响因子：
6.4
通讯作者：
Tenforde, Mark W.
中科院分区：
文献类型：
--
作者：
Lewis, Nathaniel M.;Naioti, Eric A.;Tenforde, Mark W.
在2021年3月至8月期间，使用病例对照设计评估了免疫功能正常的成年人（>= 18岁）对COVID-19住院的疫苗有效性（VE）。在1669例住院COVID-19病例（11%完全接种疫苗）和1950例RT-PCR阴性对照（54%完全接种疫苗）中，无慢性疾病患者的VE为96%（95%置信区间[CI]，93%-98%），有≥ 3类疾病患者的VE为83%（95% CI，76%-88%）。18-64岁组与≥ 65岁组之间的VE相似（P > 0.05）。无慢性疾病的成年人中，针对严重COVID-19的VE非常高，并随着合并症负担的增加而降低。
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (>= 18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with >= 3 categories of conditions. VE was similar between those aged 18-64 years versus >= 65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.