Prospective study of body mass index, weight change, and risk of adult-onset asthma in women
Prospective study of body mass index, weight change, and risk of adult-onset asthma in women
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DOI：
10.1001/archinte.159.21.2582
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发表时间：
1999-11-22
影响因子：
--
通讯作者：
Speizer, FE
中科院分区：
文献类型：
--
作者：
Camargo, CA;Weiss, ST;Speizer, FE
背景：肥胖和哮喘是常见的疾病，其患病率持续上升。尽管哮喘患者可能由于活动受限而增加体重，但体重指数（BMI）（以体重（kg）除以身高（m）的平方计算）与发生哮喘的风险之间的关系尚不清楚。方法：我们在护士健康研究11中对美国注册女护士进行了前瞻性队列研究。1991年，在排除可能死于哮喘或数据不完整的妇女后，有85911名参与者，年龄在26至46岁之间。主要结果的措施是自我报告的医生诊断的哮喘与最近使用的哮喘medication.Results：从1991年至1995年，我们确定了1596例哮喘事件。在控制9个潜在混杂因素（包括年龄、种族、吸烟、体力活动和能量摄入）的多变量模型中，1991年6个BMI增加类别的哮喘相对危险度分别为0.9、1.0（参考）、1.1、1.6、1.7和2.7（趋势P
Background: Obesity and asthma are common disorders, and their prevalence rates continue to rise. Although individuals with asthma ma) gain weight as a result of activity limitations, the relationship between body mass index (BMI), which is calculated as weight in kilograms divided by the square of height in meters, and risk of developing asthma is not known.Methods: We performed a prospective cohort study of female US registered nurses in the Nurses' Health Study 11. In 1991, after excluding women who died with probable asthma or with incomplete data, there were 85 911 participants, aged 26 to 46 years. The main outcome measure was self-report of physician-diagnosed asthma with recent use of an asthma medication.Results: From 1991 to 1995, we identified 1596 incident cases of asthma. In a multivariate model controlling for 9 potential confounding factors (including age, race, smoking, physical activity, and energy intake), the relative risks of asthma for 6 increasing categories of BMI in 1991 were 0.9, 1.0 (reference), 1.1, 1.6, 1.7, and 2.7 (P for trend