Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses.
Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses.
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DOI：
10.1371/journal.pone.0132162
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Casas I
中科院分区：
文献类型：
--
作者：
Calvo C;García-García ML;Sanchez-Dehesa R;Román C;Tabares A;Pozo F;Casas I
人腺病毒(HAdV)可引起上呼吸道和下呼吸道感染。然而，很少有大型前瞻性研究集中在需要住院的HAdv急性感染上。从2005年到2013年，对收治急性呼吸道感染的儿童进行了一项前瞻性研究。用聚合酶链式反应对鼻咽抽吸物标本进行病毒学研究，并记录临床资料。对HAdV标本进行基因分型。比较同一人群中呼吸道合胞病毒(RSV)、鼻病毒(RV)、人类博卡病毒(HBoV)和流感病毒(HBoV)的感染频率和临床病程。在2371例确诊病毒感染者中，有403例(17.2%)检出HAdV，其中154例为单病毒感染(38%)。我们对154个HAdv进行了基因分型。HAdV-3(24%)、HAdV-6(21%)和HAdV-5(20%)是最常见的基因型别。发热262例(64.9%)，缺氧194例(48%)，胸片浸润性147例(36.4%)。最常见的诊断是反复喘息或哮喘(51.7%)，毛细支气管炎(18.3%)和肺炎(11.9%)，46例(11.4%)由于病情严重而需要延长住院时间(>；7天)。将腺病毒单独感染与598例RSV、494RV、83例流感和78例HBoV单独感染进行比较。HAdV、RSV和RV感染之间存在显著的临床差异。
Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specimens of nasopharyngeal aspirate were taken for virological study by PCR and clinical data was recorded. HAdV specimens were genotyped. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. HAdV was detected in 403 cases of 2371 confirmed viral infections (17.2%) , of which 154 were single virus infections (38%). We genotyped 154 HAdVs. The most frequent genotypes were HAdV-3 (24%), HAdV-6 (21%), and HAdV-5 (20%). A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%). The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity. Adenovirus single infections were compared with single infections of 598 RSV, 494 RV, 83 influenza and 78 HBoV. Significant clinical differences were found between HAdV, RSV and RV infections.