GLUCOCORTICOIDS INDUCE ENDOTHELIN RELEASE FROM VASCULAR SMOOTH-MUSCLE CELLS BUT NOT ENDOTHELIAL-CELLS
GLUCOCORTICOIDS INDUCE ENDOTHELIN RELEASE FROM VASCULAR SMOOTH-MUSCLE CELLS BUT NOT ENDOTHELIAL-CELLS
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DOI：
10.1016/0014-2999(91)90641-3
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发表时间：
1991-06-18
影响因子：
5
通讯作者：
BLOOM, SR
中科院分区：
文献类型：
--
作者：
KANSE, SM;TAKAHASHI, K;BLOOM, SR
培养的血管平滑肌细胞能够分泌内皮素，这是一种血管收缩和有丝分裂多肽。本文观察了糖皮质激素对大鼠和兔主动脉血管平滑肌细胞释放内皮素的影响。微摩尔浓度的地塞米松和皮质醇使这两种类型的血管内皮细胞释放的内皮素增加2到5倍，但在牛主动脉内皮细胞中没有观察到这种反应。糖皮质激素似乎选择性地诱导血管平滑肌细胞释放内皮素，这可能与糖皮质激素引起的高血压有关。
Vascular smooth muscle cells in culture are capable of secreting endothelin which is a vasoconstrictor and mitogenic peptide. The effect of glucocorticoids on endothelin release from vascular smooth muscle cells of the rat and rabbit aortas was investigated. Micromolar concentrations of dexamethasone and cortisol caused a 2 to 5-fold increase in endothelin release from the two smooth muscle cell types but no such response was observed in endothelial cells of the bovine aorta. Glucocorticoids appear to selectively induce endothelin release from vascular smooth muscle cells and this may be relevant to glucocorticoid-induced hypertension.