EFFECT OF ELECTRICAL-STIMULATION OF HIPPOCAMPUS UPON CORTICOSTEROID LEVELS IN FREELY-BEHAVING, NON-STRESSED RAT
EFFECT OF ELECTRICAL-STIMULATION OF HIPPOCAMPUS UPON CORTICOSTEROID LEVELS IN FREELY-BEHAVING, NON-STRESSED RAT
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DOI：
10.1159/000122470
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发表时间：
1976-01-01
影响因子：
4.1
通讯作者：
TAYLOR, AN
中科院分区：
文献类型：
--
作者：
CASADY, RL;TAYLOR, AN
在雄性Sprague-Dawley大鼠的背侧和腹侧海马中长期植入同心双极不锈钢电极，研究海马对垂体ACTH释放的影响。每隔0.5小时从右心房插管中抽取血样。血浆皮质酮水平反映ACTH释放。30分钟的25或250-cps的电刺激海马在自由行为，非应激大鼠导致基础血浆皮质酮水平显着增加，在刺激结束时明显。在下午的实验中，刺激后，在任何海马网站与25 cps的，增加其次是一个延迟的抑制相和暂时抑制的昼夜节律上升皮质酮水平。腹侧海马刺激的抑制作用比背侧海马刺激更明显。这些差异的影响的基础进行了讨论的海马体的解剖组织。
The influence of the hippocampus upon pituitary release of ACTH was studied in male Sprague-Dawley rats which had concentric bipolar stainless steel electrodes chronically implanted in the dorsal and ventral hippocampus. Blood samples were withdrawn at 0.5-h intervals from a cannula in the right atrium. Plasma corticosterone levels reflected ACTH release. Thirty min of 25 or 250-cps electrical stimulation of the hippocampus in the freely-behaving, non-stressed rat resulted in significant increases in basal plasma corticosterone levels evident at the end of stimulation. In afternoon experiments, after stimulation at either hippocampal site with 25 cps only, the increase was followed by a delayed inhibitory phase and temporary inhibition of the circadian rise in corticosterone levels. The inhibitory effect was more pronounced with ventral than with dorsal hippocampal stimulation. The basis for these differential effects is discussed in terms of the anatomical organization of the hippocampus.