Honing in on the ATP Release Channel in Taste Cells.
Honing in on the ATP Release Channel in Taste Cells.
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深入研究味觉细胞中的 ATP 释放通道。
DOI：
10.1093/chemse/bjv035
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发表时间：
2015
期刊：
影响因子：
3.5
通讯作者：
Medler,KathrynF
中科院分区：
文献类型：
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作者：
Medler,KathrynF
过去 8 年的研究已经确定了 3 种潜在的通道，它们似乎可以响应味觉刺激而从 II 型细胞中释放 ATP。这些研究采用了不同的方法，但都提供了支持其候选通道作为 ATP 释放通道的数据。这些潜在通道包括 Pannexin 1、Connexins（30 和/或 43）以及最近的 Calhm1 通道。本期《Chemical Senses》中的两篇论文提供了令人信服的新证据，证明 Pannexin 1 不是 ATP 释放通道。托多夫等人。对 Pannexin1 敲除小鼠进行了彻底的行为分析，发现这些动物对所测试的 7 种不同味觉刺激具有与野生型小鼠相同的行为反应。范登博赫等人。对 Pannexin1 敲除小鼠的味觉神经反应进行了同样彻底的分析，发现与对照组相比没有差异。因此，当在系统水平上分析 Pannexin 1 的作用时，正常味觉感知不需要它。需要进一步的研究来确定该半通道在味觉细胞中的作用。
Studies over the last 8 years have identified 3 potential channels that appear to release ATP from Type II cells in response to taste stimuli. These studies have taken different methodological approaches but have all provided data supporting their candidate channel as the ATP release channel. These potential channels include Pannexin 1, Connexins (30 and/or 43), and most recently, the Calhm1 channel. Two papers in this issue ofChemical Sensesprovide compelling new evidence that Pannexin 1 is not the ATP release channel. Tordoff et al. did a thorough behavioral analysis of the Pannexin1 knock out mouse and found that these animals have the same behavioral responses as wild type mice for 7 different taste stimuli that were tested. Vandenbeuch et al. presented an equally thorough analysis of the gustatory nerve responses in the Pannexin1 knock out mouse and found no differences compared with controls. Thus when the role of Pannexin 1 is analyzed at the systems level, it is not required for normal taste perception. Further studies are needed to determine the role of this hemichannel in taste cells.