Prehospital stability of diazepam and lorazepam
Prehospital stability of diazepam and lorazepam
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DOI：
10.1016/s0735-6757(99)90079-7
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发表时间：
1999-07-01
影响因子：
3.6
通讯作者：
Alldredge, BK
中科院分区：
文献类型：
--
作者：
Gottwald, MD;Akers, LC;Alldredge, BK
注射用苯二氮卓类药物通常储存在救护车上供护理人员使用。我们评价了劳拉西泮和地西泮作为储存温度的函数的稳定性，地西泮（5 mg/mL）和劳拉西泮（2 mg/mL）注射液在透明玻璃注射器中在三种条件下储存长达210天：4 ℃至10 ℃（冷藏）; 15摄氏度至30摄氏度（救护车环境温度）; 37摄氏度（烘箱加热），以30天的间隔进行注射器内容物的高效液相色谱（HPLC）分析。210天后，地西泮浓度降低7%冷藏，劳拉西泮的浓度在冷藏时降低0%，在环境温度下降低10%，在37 ℃下降低75%，而地西泮在救护车上储存30天后保留其原始浓度的90%，劳拉西泮在150天后保留其原始浓度的90%。劳拉西泮浓度的降低与旧金山弗朗西斯科最高环境温度的升高相关。这些结果表明，地西泮和劳拉西泮可以储存在救护车上，当环境储存温度为30 ℃或更低时，装载劳拉西泮和地西泮的救护车应每30至60天补充一次。当药物储存温度超过30摄氏度时，需要更频繁地储存或冷藏。版权所有（C）1999 W.B.桑德斯公司
Injectable benzodiazepines are commonly stocked on ambulances for use by paramedics, We evaluated the stability of lorazepam and diazepam as a function of storage temperature, Diazepam (5 mg/mL) and lorazepam (2 mg/mL) injectable solutions were stored for up to 210 days in clear glass syringes at three conditions: 4 degrees C to 10 degrees C (refrigerated); 15 degrees C to 30 degrees C (on ambulance ambient temperature); and 37 degrees C (oven-heated), High performance liquid chromatography (HPLC) analyses of syringe contents were performed at 30-day intervals, After 210 days, the reduction in diazepam concentration was 7% refrigerated, 15% at ambient temperature, and 25% at 37 degrees C, The reduction in lorazepam concentration was 0% refrigerated, 10% at ambient temperature, and 75% at 37 degrees C, Whereas diazepam retained 90% of its original concentration for 30 days of on ambulance storage, lorazepam retained 90% of its original concentration for 150 days. The decrease in lorazepam concentration correlated with an increase in the maximum ambient temperature in San Francisco. These results suggest that diazepam and lorazepam can be stored on ambulances, When ambient storage temperatures are 30 degrees C or less, ambulances carrying lorazepam and diazepam should be restocked every 30 to 60 days. When drug storage temperatures exceed 30 degrees C, more frequent stocking or refrigeration is required. Copyright (C) 1999 by W.B. Saunders Company.