Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
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DOI：
10.1016/s0920-9964(98)00113-3
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发表时间：
1999-01-04
影响因子：
4.5
通讯作者：
Salokangas, RKR
中科院分区：
文献类型：
--
作者：
Hietala, J;Syvälahti, E;Salokangas, RKR
我们先前曾报道，与健康对照组相比，未使用过抗精神病药物的精神分裂症患者纹状体突触前多巴胺功能存在异常（希耶塔拉，J.；西瓦拉蒂，E.；武里奥，K.等人，1995年。《柳叶刀》346卷，1130 - 1131页）。在这项扩展研究中，我们探讨突触前多巴胺功能的改变是否与精神分裂症的临床症状相关。我们利用正电子发射断层扫描技术对10名未使用过抗精神病药物的精神分裂症患者和13名健康对照者的纹状体多巴胺合成能力（6 - [F - 18]氟多巴（FDOPA）摄取，Ki值）进行了研究。临床症状采用阳性和阴性症状量表（PANSS）进行评估。患者纹状体FDOPA摄取增加，且尾状核FDOPA摄取不存在不对称性（p = 0.0005），这证实了我们之前的结果。左侧纹状体FDOPA摄取（Ki）值与抑郁症状呈极显著负相关。另一方面，偏执症状与右侧壳核FDOPA摄取在趋势水平上呈正相关（rho = 0.73，p（此处原文似乎不完整）
We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvalahti, E., Vuorio, K. et al., 1995. Lancet 346, 1130-1131). In this extended study we explore whether the altered presynaptic dopamine function correlates with the clinical symptomatology in schizophrenia. Striatal dopamine synthesis capacity (6-[F-18]fluorodopa (FDOPA) uptake, K-i values) was studied with positron emission tomography in 10 neuroleptic-naive schizophrenic patients and 13 healthy controls. The clinical symptomatology was characterized with the Positive and Negative Symptom Scale (PANSS). The patients had an increased FDOPA uptake in striatum and lacked the asymmetry in caudate FDOPA uptake (p = 0.0005), confirming our earlier results. Left striatal FDOPA uptake (K-i) values correlated negatively with depressive symptoms in a highly significant manner. On the other hand, paranoid symptomatology correlated positively with right putamen FDOPA uptake at a trend level (rho = 0.73, p