Sulforaphane and related mustard oils in focus of cancer prevention and therapy
Sulforaphane and related mustard oils in focus of cancer prevention and therapy
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DOI：
10.1007/s10354-012-0163-3
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发表时间：
2013-02-01
影响因子：
0.9
通讯作者：
Buchler, Markus W.
中科院分区：
文献类型：
--
作者：
Herr, Ingrid;Lozanovski, Vladimir;Buchler, Markus W.
十字花科植物科，以前称为十字花科，含有芥子油糖苷，芥子油是通过酶法水解而成的。芥末油可以防止害虫、微生物和真菌的侵害。已知超过 120 种具有不同生物功能的不同芥末油。自古以来，这些物质就被用作天然抗生素、抗病毒药和抗真菌药。芥末油的抗氧化作用有助于防止 DNA 损伤。流行病学和实验研究表明十字花科植物或其分离物具有预防和治疗作用。研究特别深入的是芥子油萝卜硫素，西兰花及其芽苗中含有高浓度的芥子油萝卜硫素。正如最近在小鼠身上所显示的那样，萝卜硫素还针对最恶性的癌症干细胞，这些细胞不受传统癌症治疗的影响。基于这些有希望的结果，第一个针对癌症患者和富含萝卜硫素的西兰花芽的前瞻性临床研究现已在美国启动。
The plant family Brassicaceae, formerly Cruciferae, contains mustard oil glycosides, from which mustard oils are enzymatically hydrolyzed. Mustard oils offer protection from pests, microorganisms and fungi. More than 120 different mustard oils with various biological functions are known. Since ancient times, these substances are used as natural antibiotics, antiviral drugs and antimycotics. The antioxidative effect of mustard oils contributes to protection from DNA damage. Epidemiological and experimental studies have shown preventive and therapeutic effects of crucifers or isolated substances thereof. Particularly well studied is the mustard oil sulforaphane, which is contained in high concentrations in broccoli and its sprouts. As has been shown in mice recently, sulforaphane also targets the most malignant cancer stem cells, which are not affected by conventional cancer treatments. Based on these promising results, the first prospective clinical studies with cancer patients and sulforaphane-enriched broccoli sprouts have now been initiated in the United States.