Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.
Changes in sensitivity to cytotoxic agents occurring during the life history of monolayer cultures of a mouse tumour cell line.
复制标题
小鼠肿瘤细胞系单层培养物生命史期间对细胞毒性药物的敏感性发生变化。
作者：
P. Twentyman;N. Bleehen
EMT-6小鼠肿瘤细胞对阿霉素、放线菌素D、氮芥、BCNU和CCNU的剂量反应曲线。实验已经用指数生长的细胞和处于早期和晚期平台期的细胞进行。讨论的结果与其他工人在类似的系统中获得的结果的差异，特别是参考。
Dose-response curves have been obtained for the response of EMT6 mouse tumour cells in vitro to adriamycin, actinomycin D, nitrogen mustard, BCNU and CCNU. The experiments have been carried out with exponentially growing cells and with cells in early and late plateau phase. The results are discussed with particular reference to discrepancies with the results obtained by other workers in similar systems.