The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis
复制标题
DOI：
10.1164/rccm.200504-613pp
复制
发表时间：
2005-12-15
影响因子：
24.7
通讯作者：
Heifets, L
中科院分区：
文献类型：
--
作者：
Gelperina, S;Kisich, K;Heifets, L
基于纳米颗粒的药物输送系统在治疗结核病方面具有相当大的潜力。纳米颗粒作为药物载体的重要技术优势是高稳定性、高载药量、可掺入亲疏水物质以及可采用多种给药途径（包括口服和吸入）。纳米颗粒也可以被设计成允许从基质中控制（持续）药物释放。纳米颗粒的这些特性能够改善药物的生物利用度和减少给药频率，并可能解决不遵守处方治疗的问题，这是控制结核病流行的主要障碍之一。本文重点介绍了纳米技术与抗结核药物相关的一些问题。
Nanoparticle-based drug delivery systems have considerable potential for treatment of tuberculosis (TB). The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral application and inhalation. Nanoparticles can also be designed to allow controlled (sustained) drug release from the matrix. These properties of nanoparticles enable improvement of drug bioavailability and reduction of the dosing frequency, and may resolve the problem of nonadherence to prescribed therapy, which is one of the major obstacles in the control of TB epidemics. This article highlights some of the issues of nano-technology relevant to the anti-TB drugs.