Defibrination after brain-tissue destruction: A serious complication of head injury.
Defibrination after brain-tissue destruction: A serious complication of head injury.
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脑组织破坏后的去纤维：头部损伤的严重并发症。
DOI：
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发表时间：
1974
影响因子：
158.5
通讯作者：
T. Kurze
中科院分区：
文献类型：
--
作者：
S. Goodnight;G. Kenoyer;S. Rapaport;M. Patch;J. Lee;T. Kurze
摘要本研究旨在探讨急性颅脑外伤后脱髓鞘的作用。在13例创伤显然没有破坏脑组织的患者中没有观察到去脑化。相反，在13例通过直接检查确定脑组织破坏的患者中，有9例发现了脱髓鞘的证据--低纤维蛋白原血症、血清纤维蛋白原相关或纤维蛋白相关抗原水平升高以及因子V、VIII或血小板水平降低。所有9名患者的鱼精蛋白试验均呈强阳性，表明发生了血管内凝血。由于测试结果在数小时内恢复正常，因此脱钙的活跃阶段显然很短暂。然而，止血异常的严重程度足以影响颅内出血的神经系统后果。归因于微循环中纤维蛋白的临床结果（例如，微血管病性溶血性贫血或肾衰竭）。潜在的可挽救的病人智慧...
Abstract A prospective study was conducted to evaluate defibrination after acute head trauma. Defibrination was not observed in 13 patients In whom trauma apparently did not destroy brain tissue. In contrast, evidence of defibrination — hypofibrinogenemia, elevated levels of serum fibrinogen-related or fibrin-related antigen and low levels of factors V, VIII or platelets — was found in nine of 13 patients in whom brain-tissue destruction was established by direct inspection. All nine patients had a strongly positive protamine test, suggesting that intravascular coagulation had occurred. Since test results returned toward normal within hours, the active phase of defibrination apparently was brief. Nevertheless, hemostatic abnormalities were severe enough to have affected the neurologic consequences of intracranial bleeding. Clinical findings attributable to fibrin in the microcirculation (e.g., microangiopathic hemolytic anemia or renal failure) were not encountered. The potentially salvageable patient wit...