Asymmetric total synthesis of nigerone
Asymmetric total synthesis of nigerone
复制标题
DOI：
10.1021/ol062468y
复制
发表时间：
2007-02-01
期刊：
影响因子：
5.2
通讯作者：
Kozlowski, Marisa C.
中科院分区：
文献类型：
--
作者：
DiVirgilio, Evan S.;Dugan, Elizabeth C.;Kozlowski, Marisa C.
报道了手性双萘吡啶酮天然产物尼日尔酮的对映选择性合成。关键的一步是形成最终天然产物的八步异构化过程。该异构化前驱体是通过高级中间体与1,5-重氮顺-十氢化铜催化剂的不对称氧化偶联而构建的。
An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone is reported. The key step was an eight-step isomerization process to form the final natural product. The isomerization precursor was constructed via asymmetric oxidative biaryl coupling of an advanced intermediate with a 1,5-diaza-cis-decalin copper catalyst.