Sulforaphane improves cognitive function administered following traumatic brain injury.
Sulforaphane improves cognitive function administered following traumatic brain injury.
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DOI：
10.1016/j.neulet.2009.04.028
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发表时间：
2009-08-28
影响因子：
2.5
通讯作者：
Moore AN
中科院分区：
文献类型：
--
作者：
Dash PK;Zhao J;Orsi SA;Zhang M;Moore AN
最近的研究表明，萝卜硫素，一种在十字花科蔬菜中发现的天然化合物，在几种脑损伤模型中提供细胞保护。当在创伤性脑损伤（TBI）后施用时，萝卜硫素已被证明减弱血脑屏障通透性并减少脑水肿。萝卜硫素的这些有益作用已被证明涉及诱导一组细胞保护性Nrf2驱动的基因，其蛋白质产物包括自由基清除和解毒酶。然而，萝卜硫素对损伤后认知缺陷的影响尚未得到研究。在这项研究中，我们研究了萝卜硫素，当皮层撞击损伤后，可以提高海马和前额叶皮层依赖性任务测试大鼠的性能。我们的研究结果表明，萝卜硫素治疗改善了Morris水迷宫任务的表现（如在学习和平台定位过程中的探针试验过程中减少的lavin所示），并减少了工作记忆功能障碍（使用延迟匹配到位置任务进行测试）。这些行为改善仅在损伤后1小时而不是6小时开始治疗时观察到。这些研究支持使用萝卜硫素治疗TBI，并将先前观察到的保护作用扩展到包括增强认知。
Recent studies have shown that sulforaphane, a naturally occurring compound that is found in cruciferous vegetables, offers cellular protection in several models of brain injury. When administered following traumatic brain injury (TBI), sulforaphane has been demonstrated to attenuate blood-brain barrier permeability and reduce cerebral edema. These beneficial effects of sulforaphane have been shown to involve induction of a group of cytoprotective, Nrf2-driven genes, whose protein products include free radical scavenging and detoxifying enzymes. However, the influence of sulforaphane on post-injury cognitive deficits has not been examined. In this study, we examined if sulforaphane, when administered following cortical impact injury, can improve the performance of rats tested in hippocampal- and prefrontal cortex-dependent tasks. Our results indicate that sulforaphane treatment improves performance in the Morris water maze task (as indicated by decreased latencies during learning and platform localization during a probe trial) and reduces working memory dysfunction (tested using the delayed match-to-place task). These behavioral improvements were only observed when the treatment was initiated 1 hr, but not 6 hr, post-injury. These studies support the use of sulforaphane in the treatment of TBI, and extend the previously observed protective effects to include enhanced cognition.
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影响因子：
5.3
作者：
Zhang, DD;Lo, SC;Hannink, M
通讯作者：
Hannink, M
影响因子：
5.3
作者：
Zhao, Jing;Moore, Anthony N.;Dash, Pramod K.
通讯作者：
Dash, Pramod K.
影响因子：
4.1
作者：
Mikawa, S;Kinouchi, H;Chan, PH
通讯作者：
Chan, PH
影响因子：
4.2
作者：
HAMM, RJ;DIXON, CE;HAYES, RL
通讯作者：
HAYES, RL
影响因子：
5.3
作者：
Kraft, AD;Johnson, DA;Johnson, JA
通讯作者：
Johnson, JA