The neural basis of individual differences in working memory capacity: an fMRI study
The neural basis of individual differences in working memory capacity: an fMRI study
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DOI：
10.1016/s1053-8119(02)00032-0
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发表时间：
2003-03-01
期刊：
影响因子：
5.7
通讯作者：
Shibasaki, H
中科院分区：
文献类型：
--
作者：
Osaka, M;Osaka, N;Shibasaki, H
使用功能磁共振成像技术，研究了言语工作记忆的神经基础与工作记忆容量的差异。进行了听力广度测试(LST)、听力测试和记忆测试。被试分为两组：一组是工作记忆容量大的被试，根据工作记忆广度测验被标记为高广度被试(HSS)；另一组是工作记忆容量小的被试，被标记为低广度被试(LSS)。与安静对照组相比，左侧前额叶皮质(PFC)、前扣带回皮质(ACC)和颞叶语言区激活明显。与LISTEN状态相比，两组患者在LST状态下PFC的fMRI信号强度都有所增加。在ACC区域发现了不同的组别；具体地说，只有HSS组的ACC信号强度显著增加，而LSS组的信号强度没有显著增加。行为数据还表明，HSS的表现好于LSS。这些结果表明，在ACC的支持下，HSS的注意控制系统比LSS更有效。(C)2003年埃尔塞维尔科学公司(美国)。版权所有。
Using fMRI, neural substrates of verbal working memory were investigated with respect to differences in working memory capacity. Listening-span test (LST), Listen, and Remember conditions were performed. Two subjects groups were selected: those who had large working memory capacities, labeled high-span subjects (HSS) according to the working memory span test, and those who had small working memory capacities, labeled low-span subjects (LSS). Significant activation was found mainly in three regions in comparison with resting control: left prefrontal cortex (PFC), anterior cingulate cortex (ACC) and temporal language area. For both groups, fMRI signal intensity increased in PFC during the LST condition compared to the Listen condition. A group difference was found in the ACC region; specifically, a significant increase in signal intensity was observed in ACC only for the HSS group and not for the LSS group. Behavioral data also showed that the performance was better in HSS than in LSS. These results indicate that the attention controlling system, supported by ACC, is more effective in HSS compared to that of LSS. (C) 2003 Elsevier Science (USA). All rights reserved.