p63 expression is a prognostic factor in colorectal cancer
p63 expression is a prognostic factor in colorectal cancer
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DOI：
10.5301/jbm.2012.9581
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发表时间：
2012-07-01
影响因子：
2
通讯作者：
Yang, Shu-Jun
中科院分区：
文献类型：
--
作者：
Guo, Hong-Qiang;Huang, Guo-Liang;Yang, Shu-Jun
p63在某些恶性肿瘤中高表达，与肿瘤的发生、侵袭和转移有关。本研究旨在探讨p63在结直肠癌中的表达及其临床意义。采用免疫组化法检测66例大肠癌组织中p63蛋白的表达。分析p63表达与临床病理因素、无进展生存期（PFS）和总生存期（OS）的相关性。66例大肠癌中p63高表达31例（47%），低表达35例（53%）。p63水平与瘤周沉积物相关（p= 0.021）。低p63评分组和高p63评分组的5年OS率分别为49%和74%（p < 0.001）。p63低评分组和p63高评分组的5年无进展生存率分别为44%和71%（9 p < 0.001）。单因素分析显示p63表达与OS和PFS相关。多因素分析提示p63表达是影响OS的独立预后因素（p = 0.035）。总之，p63与结直肠癌的瘤周沉积呈负相关，与OS和PFS呈正相关。这些数据表明p63是CRC的潜在预后因素。
p63 is highly expressed in some malignant tumors and is associated with tumorigenesis, invasion and metastasis. The aim of our study was to evaluate the clinical significance of p63 in colorectal cancer (CRC). p63 expression was detected by immunohistochemistry in 66 CRC patients. Correlations between p63 expression and clinicopathological factors, progression-free survival (PFS) and overall survival 9OS) were analyzed. Among the 66 CRC cases, 31 cases (47%) exhibited a high score of p63 expression, while 35 cases (53%) were marked with a low score. The p63 level correlated with peritumoral deposits (p= 0.021). The 5-year OS rates in the low p63 score and high p63 score groups were, respectively, 49% and 74% (p < 0.001). The 5-year PFS rates in the low p63 score and high p63 score groups were, respectively, 44% and 71% 9p < 0.001). Univariate analysis revealed that p63 expression was correlated with OS and PFS. Multivariate analysis suggested that p63 expression was an independent prognostic factor for OS 9p= 0.035). In conclusion, p63 was negatively correlated with peritumoral deposits and positively associated with OS and PFS in CRC. The data suggest that p63 is a potential prognostic factor for CRC.