Pupillary and reaction time measures of sustained processing of negative information in depression
Pupillary and reaction time measures of sustained processing of negative information in depression
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DOI：
10.1016/s0006-3223(00)01024-6
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发表时间：
2001-04-01
影响因子：
10.6
通讯作者：
Matt, GE
中科院分区：
文献类型：
--
作者：
Siegle, GJ;Granholm, E;Matt, GE
背景：情绪信息处理的中断（即，对情绪信息的注意、记忆、解释）与抑郁症的发生和维持有关。本文介绍的研究调查了一个特别有前途的抑郁症相关的认知和心理生理学特征：在情绪刺激后4-5秒持续处理负面信息。方法：瞳孔放大的数据和反应时间收集了24个未经药物治疗的抑郁症和25个非抑郁症的成年人对情绪处理任务的反应（词汇决定和效价识别），采用特质产生的个人相关和规范的刺激。瞳孔放大被用来索引持续的认知处理致力于stimulation.Results：与预测一致，抑郁症患者特别缓慢的名字的情绪化的积极信息，并显示更大的持续处理（瞳孔放大）比nondepressed个人时，他们的注意力被导向情感方面的信息。相反的预测，抑郁症的参与者没有扩张更多的负面比积极的刺激，相比nondepressed participants.Conclusions：这些数据表明，抑郁症患者最初可能不会参加情感方面的信息，但可能会继续处理他们秒后，他们已经作出反应的信息。Biol Psychiatry 2001; 49：624-636（C）2001 Society of Biological Psychiatry.
Background: Disruptions of emotional information processing (i.e., attention to, memory for, an interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological feature of a particularly promising correlate of depression: sustained processing of negative information 4-5 sec after an emotional stimulus.Methods: Pupil dilation data and reaction times were collected from 24 unmedicated depressed and 25 nondepressed adults in response to emotional processing tasks (lexical decision and valence identification) that employed idiosyncratically generated personally relevant and normed stimuli. Pupil dilation was used to index sustained cognitive processing devoted to stimuli.Results: Consistent with predictions, depressed individuals were especially slow to name the emotionality of positive information, and displayed greater sustained processing (pupil dilation) than nondepressed individuals when their attention was directed toward emotional aspects of information. Contrary to predictions, depressed participants did not dilate more to negative than positive stimuli, compared to nondepressed participants.Conclusions: These data suggest depressed individuals may not initially attend to emotional aspects of information but may continue to process them seconds after they have reacted to the information. Biol Psychiatry 2001; 49:624-636 (C) 2001 Society of Biological Psychiatry.