Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis
Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis
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DOI：
10.1128/aac.00961-20
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发表时间：
2020-10-01
影响因子：
4.9
通讯作者：
Langelier, Charles
中科院分区：
文献类型：
--
作者：
Hao, Samantha;Abdelghany, Mazin;Langelier, Charles
银色葡萄球菌是一种与侵袭性疾病相关的新型葡萄球菌。我们报告了首例达托霉素/万古霉素耐药的S。最初以金黄色葡萄球菌（Staphylococcus aureus）的形式出现，其是从用达托霉素反复治疗复杂的血管移植物感染而发展而来的。纵向收集的分离株的全基因组测序鉴定了MprF S337 L的获得，这是一种预测增加表面电荷和排斥阳离子分子的突变。
Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus, initially speciated as Staphylococcus aureus, that developed from repeated treatment with daptomycin for a complex vascular graft infection. Whole-genome sequencing of longitudinally collected isolates identified acquisition of MprF S337L, a mutation predicted to increase surface charge and repel cationic molecules.