Differential effects of age on sequence learning and sensorimotor adaptation
Differential effects of age on sequence learning and sensorimotor adaptation
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DOI：
10.1016/j.brainresbull.2006.06.008
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发表时间：
2006-10-16
影响因子：
3.8
通讯作者：
Seidler, Rachael D.
中科院分区：
文献类型：
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作者：
Seidler, Rachael D.
虽然许多研究都记录了老年人学习新的手动运动技能的能力下降，但研究并没有直接比较老年人在相同任务范式的背景下学习序列与适应感觉运动扰动的能力，尽管支持这两种类型学习的潜在神经机制和策略过程存在差异。本研究的目的是利用这些任务的差异，以确定是否老化的结果在一个普遍的或更具体的技能学习缺陷。年轻和年长的成年受试者学习做出一系列动作，适应两种视觉旋转中的一种，或适应改变的显示增益，所有这些都是在执行相同的基本手动操纵杆瞄准任务的同时。虽然老年人表现出正常的序列学习相比，年轻人，他们表现出障碍，在所有三个适应任务。老年人的这些适应缺陷与高血压运动和速度调制减少相比，在年轻人中看到的。这些数据表明，老年人在学习小脑介导的运动技能方面可能有更大的困难。(c)2006年爱思唯尔公司All rights reserved.
Although many studies have documented declines in the ability of the elderly to learn new manual motor skills, studies have not directly compared the capacity of older adults to learn sequences versus adapt to sensorimotor perturbations within the context of the same task paradigm, despite differences in the underlying neural mechanisms and strategic processes supporting the two types of learning. The purpose of the current study was to exploit these task differences in an effort to determine whether aging results in a generalized or more specific skill learning deficit. Groups of young and older adult subjects learned to make a sequence of actions, adapted to one of two visuomotor rotations, or adapted to an altered gain of display, all while performing the same basic manual joystick aiming task. While the older adults exhibited normal sequence learning in comparison to the young adults, they exhibited impairments in all three of the adaptation tasks. These deficits in adaptation for the older adults were associated with hypometric movements and reduced velocity modulation in comparison to that seen in the younger adults. These data suggest that older adults may have greater difficulty with learning cerebellar-mediated motor skills. (c) 2006 Elsevier Inc. All rights reserved.