Surface-modified protein nanospheres as potential antiviral agents
Surface-modified protein nanospheres as potential antiviral agents
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DOI：
10.1039/c2cc33448h
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Sarid, Ronit
中科院分区：
文献类型：
--
作者：
Baram-Pinto, Dana;Shukla, Sourabh;Sarid, Ronit
一个新的应用程序的表面修饰的蛋白质纳米球作为潜在的抗病毒药物的说明。通过一步声化学法制备了牛血清白蛋白纳米球，其表面与巯基乙磺酸共价结合，以化学和静电模拟细胞硫酸乙酰肝素。纳米球有效地抑制HSV-1感染。
A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.