Caries inhibitory activity of cacao bean husk extract in in-vitro and animal experiments
Caries inhibitory activity of cacao bean husk extract in in-vitro and animal experiments
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DOI：
10.1016/s0003-9969(00)00042-x
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发表时间：
2000-08-01
影响因子：
3
通讯作者：
Matsumoto, M
中科院分区：
文献类型：
--
作者：
Ooshima, T;Osaka, Y;Matsumoto, M
研究了可可豆壳提取物（CBH）对体外变形链球菌致龋特性的抑制作用，以及对感染变形链球菌的无特定病原体Sprague-Dawley大鼠龋齿发展的抑制作用。CBH降低了几乎所有口腔链球菌的生长速度，导致产酸减少。此外，CBH显著抑制变形链球菌MT 8148 R和远缘链球菌6715的葡糖基转移酶合成不溶性葡聚糖。因此，CBH也抑制了变形链球菌的蔗糖依赖性细胞粘附。CBH在饮用水中的管理导致显着减少龋齿的发展和牙菌斑积累感染链球菌的大鼠。sobrinus 6715或链球菌。最低抑龋浓度为1.0mg/ml。结果表明，CBH具有较强的防龋作用。(C)2000爱思唯尔科技有限公司版权所有。
Cacao bean husk extract (CBH) was examined for inhibitory effects on the caries-inducing properties of mutans streptococci in vitro and on caries development in specific pathogen-free Sprague-Dawley rats infected with mutans streptococci. CBH reduced the growth rate of almost all oral streptococci examined, which resulted in the reduction of acid production. Furthermore, insoluble glucan synthesis by the glucosyltransferases from Streptococcus mutans MT8148R and Streptococcus sobrinus 6715 was significantly inhibited by CBH. Hence, the sucrose-dependent cell adherence of mutans streptococci was also depressed by CBH. The administration of CBH in drinking water resulted in significant reductions of caries development and dental plaque accumulation in rats infected with either Strep. sobrinus 6715 or Strep. mutans MT8148R, and the minimum cariostatic concentration was 1.0 mg/ml. These results indicate that CBH possesses powerful anticariogenic potential. (C) 2000 Elsevier Science Ltd. All rights reserved.