SALIVARY TESTOSTERONE LEVELS AND THE PROGRESS OF PUBERTY IN THE NORMAL BOY
SALIVARY TESTOSTERONE LEVELS AND THE PROGRESS OF PUBERTY IN THE NORMAL BOY
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DOI：
10.1111/j.1365-2265.1989.tb01431.x
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发表时间：
1989-05-01
影响因子：
3.2
通讯作者：
RATCLIFFE, SG
中科院分区：
文献类型：
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作者：
BUTLER, GE;WALKER, RF;RATCLIFFE, SG
在爱丁堡生长研究中，测量了84名7.3-16.2岁男孩的唾液睾酮（ST）水平。匹配的血浆/唾液样本之间的相关系数为0.88。在连续4个月的大多数儿童中，从每月0900至2100 h的一天内采集6个样本。平均每日ST水平显示每个青春期阶段（生殖器（G）和阴毛（PH））之间显著升高。一旦平均睾丸体积（MTV）达到10 ml，ST的上升变得更加迅速。通过对数尺度上的个体曲线拟合和余弦分析来评估昼夜节律。一个节奏是目前青春期前和发展成一个模式类似的成人节奏的阶段G3。ST的月上升率在G4阶段最大。在MTV增加到3 ml之前，可立即检测到ST水平的显著升高。这使得在睾丸体积为3 ml时可以更早地识别青春期的临床发作，在该组中发生在10.9（SD 0.9）岁时。ST是一种非侵入性和敏感的方法，用于连续监测青春期前和青春期男孩的性腺功能。
Salivary testosterone (ST) levels were measured in 84 boys aged 7.3-16.2 from the Edinburgh Growth Study. The correlation coefficient between matched plasma/saliva samples was 0.88. Six samples were collected over the course of one day from 0900 to 2100 h each month in the majority of the children for 4 consecutive months. Mean daily ST levels showed a significant rise between each pubertal stage (genital (G) and pubic hair (PH)). The rise in ST became more rapid once a mean testicular volume (MTV) of 10 ml had been reached. The diurnal rhythm was assessed by individual curve fitting on the log scale and by cosinor analysis. A rhythm was present prepubertally and developed into a pattern similar to that of the adult rhythm by stage G3. The monthly rate of rise of ST was greatest at stage G4. A significant rise in ST levels was detectable immediately prior to an increase in MTV to 3 ml. This allowed earlier recognition of the clinical onset of puberty at testicular volume of 3 ml, which in this group occurred at 10.9 (SD 0.9) years. ST is a non-invasive and sensitive method for the serial monitoring of gonadal function in the prepubertal and adolescent boy.