Visible Light Photoredox Cross-Coupling of Acyl Chlorides with Potassium Alkoxymethyltrifluoroborates: Synthesis of α-Alkoxyketones.
Visible Light Photoredox Cross-Coupling of Acyl Chlorides with Potassium Alkoxymethyltrifluoroborates: Synthesis of α-Alkoxyketones.
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DOI：
10.1021/acs.orglett.5b03705
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发表时间：
2016-02-19
期刊：
影响因子：
5.2
通讯作者：
Molander GA
中科院分区：
文献类型：
--
作者：
Amani J;Sodagar E;Molander GA
发展了一种可见光单电子转移光氧化还原交叉偶联法合成α-烷氧基酮。在该方法中，不同的脂肪族和芳香族酰氯成功地与不同结构的烷氧基甲基三氟硼酸钾偶联，高产率地制备了相应的α-烷氧基酮。在这种操作简单和温和的交叉偶联方案中，通过烷基硼化学和光氧化还原/Ni催化所特有的键连接，从实验室稳定的起始材料一步获得所需的酮。
A visible-light, single-electron-transfer (SET), photoredox cross-coupling for the synthesis of α-alkoxyketones has been developed. In this method, various aliphatic and aromatic acyl chlorides were successfully coupled with structurally diverse potassium alkoxymethyltrifluoroborates, producing the corresponding α-alkoxyketones with high yields. In this operationally simple and mild cross-coupling protocol, the desired ketones are obtained in one step from bench stable starting materials by a bond connection that is unique to both alkylboron chemistry and photoredox/Ni catalysis.