Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells
Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells
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DOI：
10.1080/01635589809514644
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发表时间：
1998-01-01
影响因子：
2.9
通讯作者：
Kuttan, G
中科院分区：
文献类型：
--
作者：
Menon, LG;Kuttan, R;Kuttan, G
研究了两种膳食大豆黄酮染料木黄酮和大豆黄酮对B16 F-10黑色素瘤细胞诱导的C57 BL/6小鼠肺转移的抑制作用。在200 μ mol/kg体重下，木黄酮显著抑制（53.6%，p < 0.001）肺肿瘤结节形成。肺胶原羟脯氨酸含量和血清唾液酸水平，转移的标志物，也显着低于这些动物比未经处理的荷瘤动物。染料木黄酮治疗还增加了荷瘤动物的寿命（47.7%，p < 0.001）。黄豆苷元对B16 F-10黑色素瘤细胞诱导的肺转移无明显抑制作用。
Two dietary soybean isoflavones, genistein and daidzein, were studied for the inhibition of lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. The isoflavone genistein at 200 mu mol/kg body wt significantly inhibited (53.6%, p < 0.001) lung tumor nodule formation. The lung collagen hydroxyproline content and the serum sialic acid level, a marker of metastasis, were also significantly lower in these animals than in untreated tumor-bearing animals. Genistein treatment also increased the life span of the tumor-bearing animals (47.7%, p < 0.001). The isoflavone daidzein had no significant effect on the reduction of lung metastasis induced by B16F-10 melanoma cells.