The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer
The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer
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DOI：
10.1016/s1875-5364(19)30089-5
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发表时间：
2019-10-01
影响因子：
4.6
通讯作者：
Hua Qian
中科院分区：
文献类型：
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作者：
Wan Liang-Qin;Tan Yan;Hua Qian
非小细胞肺癌（Non-small cell lung cancer，NSCLC）占所有肺部恶性肿瘤的80%~ 85%，良好的诊断和预后是提高其生存率的关键。肿瘤相关巨噬细胞（TAM）大量存在于多种癌症类型中，TAM在肿瘤生物学中的作用及其在癌症中的预后价值成为人们感兴趣的主要话题。在肿瘤微环境中的各种刺激后，TAM发展成M1（肿瘤抑制）表型或M2（肿瘤促进）表型。近年来的研究表明，中药单体通过M1/M2调节对非小细胞肺癌有明显的抑制作用。由于中药单体主要包括萜类、黄酮类、多糖类、天然多酚类和生物碱类五大类。因此，本文将从这五个方面探讨中药单体对TAM的调节作用。此外，TAMs作为治疗靶点的潜在作用将被讨论。
Non-small cell lung cancer (NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages (TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1 (tumor-inhibitory) phenotype or M2 (tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine (TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed.