Functional Nanopores Enabled with DNA
Functional Nanopores Enabled with DNA
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DNA 实现功能性纳米孔
DOI：
10.1002/ange.202303103
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发表时间：
2023
影响因子：
--
通讯作者：
Xing Y
中科院分区：
文献类型：
--
作者：
Xing Y
跨膜纳米孔被用于无标记单分子传感和下一代便携式核酸测序，并在生物学、生物物理学和合成生物学中作为强大的研究工具。天然形成的蛋白质和多肽孔，以及合成的无机纳米孔，都用于这些应用中，但有其局限性。通过用DNA链对现有的孔进行功能化，并用DNA纳米技术创建一种全新的纳米孔，可以大大扩展纳米孔的结构和功能。本文概述了功能DNA纳米孔在这一领域的进展，并概述了开拓新应用的进展。
Membrane‐spanning nanopores are used in label‐free single‐molecule sensing and next‐generation portable nucleic acid sequencing, and as powerful research tools in biology, biophysics, and synthetic biology. Naturally occurring protein and peptide pores, as well as synthetic inorganic nanopores, are used in these applications, with their limitations. The structural and functional repertoire of nanopores can be considerably expanded by functionalising existing pores with DNA strands and by creating an entirely new class of nanopores with DNA nanotechnology. This review outlines progress in this area of functional DNA nanopores and outlines developments to open up new applications.