Receptor-Targeted Fluorescence-Guided Surgery With Low Molecular Weight Agents.
Receptor-Targeted Fluorescence-Guided Surgery With Low Molecular Weight Agents.
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DOI：
10.3389/fonc.2021.674083
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发表时间：
2021
影响因子：
4.7
通讯作者：
Azhdarinia A
中科院分区：
文献类型：
--
作者：
Hernandez Vargas S;Lin C;Tran Cao HS;Ikoma N;AghaAmiri S;Ghosh SC;Uselmann AJ;Azhdarinia A
癌症手术仍然是大多数实体瘤的主要治疗选择，如果所有的恶性细胞都被切除，手术是可以治愈的。外科医生历来依赖视觉和触觉线索来最大限度地切除肿瘤，但临床数据表明，复发的部分原因是癌症切除不完全。因此，在手术室中引入能够增强肿瘤可视化能力的技术是一种迫切的需求。这些技术有可能通过实时检测手术边缘、亚临床残留疾病、淋巴结转移和同步/异时性肿瘤，彻底改变手术护理标准。近红外（NIRF）光谱荧光引导手术（FGS）作为一种术中成像方式显示出巨大的前景。越来越多的临床研究表明，肿瘤选择性FGS药物可以提高荧光比非靶向染料的预测价值。虽然nif标记的大分子（即抗体）在肿瘤选择性FGS药物的广泛临床翻译中处于领先地位，但肽和小分子正在成为有价值的替代品。在这里，我们首先回顾了最新的有前途的低分子量药物的FGS临床开发；然后讨论了新兴肿瘤选择性FGS技术的意义、应用和限制。
Cancer surgery remains the primary treatment option for most solid tumors and can be curative if all malignant cells are removed. Surgeons have historically relied on visual and tactile cues to maximize tumor resection, but clinical data suggest that relapse occurs partially due to incomplete cancer removal. As a result, the introduction of technologies that enhance the ability to visualize tumors in the operating room represents a pressing need. Such technologies have the potential to revolutionize the surgical standard-of-care by enabling real-time detection of surgical margins, subclinical residual disease, lymph node metastases and synchronous/metachronous tumors. Fluorescence-guided surgery (FGS) in the near-infrared (NIRF) spectrum has shown tremendous promise as an intraoperative imaging modality. An increasing number of clinical studies have demonstrated that tumor-selective FGS agents can improve the predictive value of fluorescence over non-targeted dyes. Whereas NIRF-labeled macromolecules (i.e., antibodies) spearheaded the widespread clinical translation of tumor-selective FGS drugs, peptides and small-molecules are emerging as valuable alternatives. Here, we first review the state-of-the-art of promising low molecular weight agents that are in clinical development for FGS; we then discuss the significance, application and constraints of emerging tumor-selective FGS technologies.
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影响因子：
9
作者：
Dip F;Boni L;Bouvet M;Carus T;Diana M;Falco J;Gurtner GC;Ishizawa T;Kokudo N;Lo Menzo E;Low PS;Masia J;Muehrcke D;Papay FA;Pulitano C;Schneider-Koraith S;Sherwinter D;Spinoglio G;Stassen L;Urano Y;Vahrmeijer A;Vibert E;Warram J;Wexner SD;White K;Rosenthal RJ
通讯作者：
Rosenthal RJ
影响因子：
4.1
作者：
Cho, Steve S.;Jeon, Jun;Lee, John Y. K.
通讯作者：
Lee, John Y. K.
影响因子：
2.3
作者：
Cho, Steve S.;Zeh, Ryan;Lee, John Y. K.
通讯作者：
Lee, John Y. K.
影响因子：
9.3
作者：
Duijzentkunst, Daan A. Smit;Kwekkeboom, Dik J.;Bodei, Lisa
通讯作者：
Bodei, Lisa
DOI：
10.1155/2015/469047
发表时间：
2015
期刊：
International journal of molecular imaging
影响因子：
--
作者：
De Jesus E;Keating JJ;Kularatne SA;Jiang J;Judy R;Predina J;Nie S;Low P;Singhal S
通讯作者：
Singhal S