Maternal care, isolation-induced infant ultrasonic calling, and their relations to adult anxiety-related behavior in the rat.
Maternal care, isolation-induced infant ultrasonic calling, and their relations to adult anxiety-related behavior in the rat.
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DOI：
10.1037/0735-7044.122.2.310
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发表时间：
2008-04
影响因子：
1.9
通讯作者：
M. Wöhr;R. Schwarting
中科院分区：
文献类型：
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作者：
M. Wöhr;R. Schwarting
在大鼠中，母亲护理的变化会影响焦虑相关行为的稳定个体差异的发展。在这里，有人问这种依赖于经验的差异是否可以在生命早期就被发现。作为衡量幼崽焦虑的措施，使用隔离诱导的超声波发声，并测试了它们对不同母体行为的依赖性，即舔、检索行为和对幼崽叫声回放的反应。与报道的母性护理水平高或低的成年大鼠的差异一致，很少被舔的后代似乎更焦虑，因为当它们与母亲和幼崽分开时，它们会发出更多的叫声。基于这些发现，研究人员检查了婴儿的叫声是否可以作为成人焦虑相关行为的预测因子。结果表明，婴儿的叫声发射与恐惧条件反射期间的不动和叫声呈负相关。这些关系似乎至少部分是通过母亲的照顾来调节的。总的来说，测量超声波发声可以提供有关婴儿和成年大鼠情感特征的信息，这为研究生命早期的情绪发展提供了机会。
In the rat, variations in maternal care affect the development of stable individual differences in anxiety-related behavior. Here, it was asked whether such experience-dependent differences can be detected already during early life. As a measure for anxiety in pups, isolation-induced ultrasonic vocalizations were used, and their dependency on different maternal behaviors, namely licking, retrieval behavior, and responsiveness to playback of pup calls, was tested. Consistent with reported differences of adult rats with high or low levels of maternal care experienced, the rarely licked offspring appeared to be more anxious, since they emitted more calls when separated from their mother and litter. Based on these findings, it was examined whether infant calling can be used as a predictor of adult anxiety-related behavior. Results show that infant call emission was negatively correlated with immobility and calling during fear conditioning. These relationships seem to be mediated at least partly by maternal care. In total, measuring ultrasonic vocalizations can provide information about an affective trait of infant and adult rats, which gives the opportunity to study the development of emotionality from early life onward.