Water Compatible Hypophosphites-d2 Reagents: Deuteration Reaction via Deutero-deiodination in Aqueous Solution
Water Compatible Hypophosphites-d2 Reagents: Deuteration Reaction via Deutero-deiodination in Aqueous Solution
复制标题
与水相容的次磷酸盐-d2 试剂：在水溶液中通过氘代脱碘进行氘化反应
DOI：
10.1021/acs.orglett.0c00001
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Qian Wan
中科院分区：
文献类型：
--
作者：
Zejin Song;Jing Zeng;Ting Li;Xiang Zhao;Jing Fang;Lingkui Meng;Qian Wan
Contrary to conventional deuteration approaches which typically entail deuterated solvents and/or moisture exclusion, an unprecedented deutero-deiodination reaction attainable in aqueous (H2O) solution is presented herein. By utilizing the stability of inorganic deuterated calcium/sodium hypophosphites against wayward H/D isotopic exchange within pH 2.5–11.7, these shelf-stable, nontoxic, cost-effective, and environmentally benign deuteration reagents mediate deuteration of a broad range alkyl and aryl iodides with ample isotopic incorporation in aqueous (H2O) solution.
