Metabolic impact of estrogen signalling through ERalpha and ERbeta
Metabolic impact of estrogen signalling through ERalpha and ERbeta
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DOI：
10.1016/j.jsbmb.2010.06.012
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发表时间：
2010-10-01
影响因子：
4.1
通讯作者：
Kintscher, Ulrich
中科院分区：
文献类型：
--
作者：
Foryst-Ludwig, Anna;Kintscher, Ulrich
作用于雌激素受体α（ER α）和β（ER β）的雌激素被认为是葡萄糖稳态和脂质代谢的重要调节剂。ER属于核激素受体家族，主要作为配体激活的转录因子发挥作用。两种ER都在代谢组织如脂肪组织、骨骼肌、肝脏和胰腺以及中枢神经系统中表达。这两种内质网的表达模式在物种、性别和特定组织中存在差异，本文就内质网对糖脂代谢的关键作用作一综述。ER alpha似乎主要介导雌激素的有益代谢作用，例如抗脂肪生成、改善胰岛素敏感性和糖耐量以及减轻体重/脂肪量。相反，ER β激活似乎不利于维持正常的血糖和脂质稳态。将讨论这两种受体在相关组织中的代谢作用。(c)2010爱思唯尔有限公司版权所有。
Estrogens, acting on both estrogen receptors alpha (ERalpha) and beta (ERbeta) are recognized as important regulators of glucose homeostasis and lipid metabolism. ERs belong to the family of nuclear hormone receptors which mainly act as ligand activated transcription factors. Both ERs are expressed in metabolic tissue such as adipose tissue, skeletal muscle, liver and pancreas, as well as in the central nervous system. Expression pattern of both ERs differ between species, sexes, and specific tissues.The present review will focus on the key effects of ERs on glucose- and lipid metabolism. It appears that ERalpha mainly mediates beneficial metabolic effects of estrogens such as anti-lipogenesis, improvement of insulin sensitivity and glucose tolerance, and reduction of body weight/fat mass. In contrast, ERbeta activation seems to be detrimental for the maintenance of regular glucose and lipid homeostasis. Metabolic actions of both receptors in relevant tissues will be discussed. (c) 2010 Elsevier Ltd. All rights reserved.