Specificity of noninvasive blood glucose sensing using optical coherence tomography technique: a pilot study
Specificity of noninvasive blood glucose sensing using optical coherence tomography technique: a pilot study
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DOI：
10.1088/0031-9155/48/10/310
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发表时间：
2003-05-21
影响因子：
3.5
通讯作者：
Esenaliev, RO
中科院分区：
文献类型：
--
作者：
Larin, KV;Motamedi, M;Esenaliev, RO
对糖尿病患者的血糖浓度进行无创监测将显着减少与该疾病相关的并发症和死亡率。在本文中，我们通过实验和理论研究了光学相干断层扫描（OCT）技术无创血糖监测的特异性。 OCT 图像和信号是从尤卡坦微型猪和新西兰兔子的皮肤获得的。获得的结果表明：（1）几种体内渗透剂可以改变间质液（ISF）和组织中散射中心之间的折射率失配，但葡萄糖的效果大约高一到两个数量级； (2)生理范围内(3-30 mM)的ISF葡萄糖浓度的增加可能由于细胞体积的变化而使散射系数降低0.22% mM(-1)； (3) OCT 信号斜率的稳定性取决于组织异质性和运动伪影； (4) 适度的皮肤温度波动 (+/-1 摄氏度) 不会降低基于 OCT 的葡萄糖传感器的准确性和特异性，但是大量的皮肤加热或冷却 (几摄氏度) 会显着改变 OCT 信号斜率。这些结果表明OCT技术可以在正常生理条件下提供足够特异性的血糖浓度监测。
Noninvasive monitoring of blood glucose concentration in diabetic patients would significantly reduce complications and mortality associated with this disease. In this paper, we experimentally and theoretically studied specificity of noninvasive blood glucose monitoring with the optical coherence tomography (OCT) technique. OCT images and signals were obtained from skin of Yucatan micropigs and New Zealand rabbits. Obtained results demonstrate that: (1) several body osmolytes may change the refractive index mismatch between the interstitial fluid (ISF) and scattering centres in tissue, however the effect of the glucose is approximately one to two orders of magnitude higher; (2) an increase of the ISF glucose concentration in the physiological range (3-30 mM) may decrease the scattering coefficient by 0.22% mM(-1) due to cell volume change; (3) stability of the OCT signal slope is dependent on tissue heterogeneity and motion artefacts; and (4) moderate skin temperature fluctuations (+/-1 degreesC) do not decrease accuracy and specificity of the OCT based glucose sensor, however substantial skin heating or cooling (several degreesC) significantly change the OCT signal slope. These results suggest that the OCT technique may provide blood glucose concentration monitoring with sufficient specificity under normal physiological conditions.