A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen.
A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen.
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DOI:
10.4161/onci.19366
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发表时间:
2012-07-01
期刊:
影响因子:
7.2
通讯作者:
Porgador A
中科院分区:
文献类型:
--
作者:
Rosental B;Hadad U;Brusilovsky M;Campbell KS;Porgador A
We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.
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