A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen.

A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen.
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DOI:
10.4161/onci.19366
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发表时间:
2012-07-01
期刊:
影响因子:
7.2
通讯作者:
Porgador A
Porgador A
中科院分区:
医学2区
文献类型:
--
作者:
Rosental B;Hadad U;Brusilovsky M;Campbell KS;Porgador A

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我们最近报道了增殖细胞核抗原(PCNA)作为NK细胞激活受体NKp44的配体,它意外地触发了抑制作用。已经报道了相关NK细胞受体对核蛋白如PCNA的识别。因此,肿瘤细胞中PCNA的广泛上调可能促进免疫逃避。
We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.
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