Active hepatic capacitance responses to neural and humoral stimuli in dogs.
Active hepatic capacitance responses to neural and humoral stimuli in dogs.
复制标题
狗对神经和体液刺激的主动肝电容反应。
DOI：
10.1152/ajpheart.1982.242.6.h1000
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Rothe,CF
中科院分区：
文献类型：
--
作者：
Bennett,TD;MacAnespie,CL;Rothe,CF
在肝神经刺激期间或在肝内动脉输注组胺（0.01-1 mg/l）或肾上腺素（0.05 mg/l）期间，在泵灌注的狗肝脏中研究了肝电容的主动变化。以5脉冲/s（pps）的速度进行肝神经刺激可使肝血容量减少76 +/- 39（SD）ml/kg组织，并使表观肝顺应性从恒定流量灌注的对照值25.6 +/- 9.3 ml.kg-1.mmHg-1降低36%。在肝动脉压恒定的情况下，5 pps刺激使肝动脉流量降低至对照的16%;排出的体积为91 +/- 33 ml/kg。肾上腺素引起肝动脉收缩，主动排出71 ml/kg血液，肝顺应性降低约30%。组胺显著降低肝血管顺应性，降低门静脉传导性，增加肝动脉传导性，并使表观肝血容量增加一倍。肝静脉压升高、肝神经刺激、肾上腺素，尤其是组胺，导致液体从肝血管系统中显著滤过。我们的结论是，显着的主动电容变化和跨正弦流体过滤可以诱导犬肝脏神经和激素刺激。
Active changes in hepatic capacitance were studied in pump-perfused dog livers during hepatic nerve stimulation or during intrahepatic arterial infusion of histamine (0.01-1 mg/l) or epinephrine (0.05 mg/l). Hepatic nerve stimulation at 5 pulses/s (pps) reduced hepatic blood volume by 76 +/- 39 (SD) ml/kg tissue and decreased the apparent hepatic compliance 36% from a control value of 25.6 +/- 9.3 ml.kg-1.mmHg-1, with constant flow perfusion. With a constant hepatic arterial pressure, 5 pps stimulation decreased hepatic arterial flow to 16% of control; the volume expelled was 91 +/- 33 ml/kg. Epinephrine caused hepatic artery constriction, the active expulsion of 71 ml/kg of blood, and a decrease of about 30% in hepatic compliance. Histamine dramatically reduced the hepatic vascular compliance, decreased the portal venous conductance, increased hepatic arterial conductance, and caused the apparent hepatic blood volume to double. Increased hepatic venous pressure, hepatic nerve stimulation, epinephrine, and, especially, histamine caused a significant filtration of fluid from the hepatic vasculature. We conclude that significant active capacitance changes and transsinusoidal fluid filtration can be induced in the canine liver by neural and hormonal stimuli.