Neural evidence for dissociable components of task-switching
Neural evidence for dissociable components of task-switching
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DOI：
10.1093/cercor/bhi127
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发表时间：
2006-04-01
期刊：
影响因子：
3.7
通讯作者：
Bunge, SA
中科院分区：
文献类型：
--
作者：
Crone, EA;Wendelken, C;Bunge, SA
检索和灵活切换任务规则的能力被视为认知控制的重要组成部分。人们通常认为外侧前额叶皮层（latPFC）对规则之间的转换很重要。然而，与规则转换相关的激活在latPFC中比在内侧PFC（特别是前辅助运动区）中观察到的可靠性低。在这项研究中，我们测试的假设，内侧PFC是重要的任务集的重新配置，而latPFC是重要的检索，维护和实施相关的规则（即规则表示）。20名年轻人参加了一项功能性磁共振成像研究，在这项研究中，他们根据指导性提示确定了对目标刺激的正确反应。对于二价目标，适当的响应取决于当前的相关规则。相反，单价靶标总是与相同的反应相关。感兴趣的大脑区域的特点是根据他们的反应，二价和单价的目标，在两个规则开关和规则重复试验。这些数据支持了这一假设，即规则表征和任务集重构是可分离的认知过程，分别与latPFC和medial PFC的可分离的神经激活相关。后顶叶皮层，基底神经节和头外侧PFC的激活配置文件也进行了检查和讨论。
The ability to retrieve and flexibly switch between task rules is seen as an important component of cognitive control. It is often assumed that lateral prefrontal cortex (latPFC) is important for switching between rules. However, activation associated with rule-switching is less reliably observed in latPFC than in medial PFC (specifically, pre-supplementary motor area). In this study, we tested the hypothesis that medial PFC is important for reconfiguration of task sets, whereas latPFC is important for retrieving, maintaining and implementing relevant rules (i.e. rule representation). Twenty young adults participated in a functional magnetic resonance imaging study in which they determined the correct response to a target stimulus on the basis of an instructional cue. For bivalent targets, the appropriate response depended on the currently relevant rule. In contrast, univalent targets were always associated with the same response. Brain regions of interest were characterized according to their responsiveness to bivalent and univalent targets, on both rule-switch and rule-repetition trials. The data support the hypothesis that rule representation and task-set reconfiguration are separable cognitive processes, associated with dissociable neural activation in latPFC and medial PFC, respectively. Activation profiles of posterior parietal cortex, basal ganglia and rostrolateral PFC are also examined and discussed.