Latency modulation of collicular neurons induced by electric stimulation of the auditory cortex in Hipposideros pratti: In vivo intracellular recording.
Latency modulation of collicular neurons induced by electric stimulation of the auditory cortex in Hipposideros pratti: In vivo intracellular recording.
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DOI：
10.1371/journal.pone.0184097
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Chen QC
中科院分区：
文献类型：
--
作者：
Peng K;Peng YJ;Wang J;Yang MJ;Fu ZY;Tang J;Chen QC
在听觉通路中，下丘(IC)接受并整合来自下部听觉核团、对侧IC和听觉皮质(AC)的兴奋性和抑制性输入，然后将这些输入上传到丘脑和皮质。同时，AC调制IC神经元的声音信号处理，包括它们的潜伏期(即第一峰潜伏期)。兴奋性和抑制性皮质分离投射可分别缩短和延长IC神经元的潜伏期。然而，IC神经元皮质分离潜伏期调制的突触机制仍不清楚。因此，本研究通过活体细胞内记录以及声学和局域电刺激来探讨这些机制。IC神经元的AC潜伏期调制可能受峰前除极时间、峰前超极化持续时间和峰起时的影响。这项研究提出了一种有效的策略，用于确定上传到丘脑和皮质的听觉信息的时序。
In the auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from the lower auditory nuclei, contralateral IC, and auditory cortex (AC), and then uploads these inputs to the thalamus and cortex. Meanwhile, the AC modulates the sound signal processing of IC neurons, including their latency (i.e., first-spike latency). Excitatory and inhibitory corticofugal projections to the IC may shorten and prolong the latency of IC neurons, respectively. However, the synaptic mechanisms underlying the corticofugal latency modulation of IC neurons remain unclear. Thus, this study probed these mechanisms via in vivo intracellular recording and acoustic and focal electric stimulation. The AC latency modulation of IC neurons is possibly mediated by pre-spike depolarization duration, pre-spike hyperpolarization duration, and spike onset time. This study suggests an effective strategy for the timing sequence determination of auditory information uploaded to the thalamus and cortex.
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