The influence of mRNA stability on glucose transporter (GLUT1) gene expression.
The influence of mRNA stability on glucose transporter (GLUT1) gene expression.
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DOI：
10.1006/bbrc.1999.1328
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发表时间：
1999-09
影响因子：
3.1
通讯作者：
C. Qi;P. Pekala
中科院分区：
文献类型：
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作者：
C. Qi;P. Pekala
改变葡萄糖转运活性的一种机制是通过改变转录物稳定性来调节转运蛋白的细胞含量。已显示受调节的mRNA衰变在控制转录后基因表达中起重要作用。作为该调节的关键元件，所涉及的是信息的3 '-非翻译区（UTR）。几个实验室最近的工作集中在葡萄糖转运蛋白（GLUT 1）mRNA的3 '-UTR内的序列基序，这些序列基序作为不稳定或稳定元件，以及特定蛋白对这些元件的识别。在这篇综述中，我们解决了几个关键的研究，其中每一个都确定了在GLUT 1的3 '-UTR的转录本稳定性的控制中所涉及的元素，并证明这些序列基序被识别的特异性结合蛋白。
One mechanism for modification of glucose transport activity occurs through regulation of the cellular content of transporter protein by alteration of transcript stability. Regulated mRNA decay has been shown to play an important role in control of posttranscriptional gene expression. Implicated, as a pivotal element in this regulation is the 3'-untranslated region (UTR) of the message. Recent work from several labs has focused on sequence motifs within the 3'-UTR of glucose transporter (GLUT1) mRNA that serve as destabilizing or stabilizing elements and recognition of these elements by specific proteins. In this review, we address several critical studies each of which has identified elements in the GLUT1 3'-UTR that are involved in the control of transcript stability and demonstrated that these sequence motifs are recognized by specific binding proteins.