Effect of gastric banding on aminoterminal pro-brain natriuretic peptide in the morbidly obese
Effect of gastric banding on aminoterminal pro-brain natriuretic peptide in the morbidly obese
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DOI：
10.1038/oby.2003.99
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发表时间：
2003-06-01
期刊：
影响因子：
--
通讯作者：
Prager, R
中科院分区：
文献类型：
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作者：
Hanusch-Enserer, U;Hermann, KM;Prager, R
目的：与脑利钠肽一样，氨基端脑利钠肽前体（NT-proBNP）可能在检测左心室肥厚和/或左心室功能障碍方面具有诊断价值。本研究的目的是探讨病态肥胖与NT-proBNP之间的关系以及减肥对该参数的影响。研究方法和步骤：34例病态肥胖患者行腹腔镜可调节胃束带术（LAGB）。在术前和术后12个月测量NT-proBNP水平。结果：LAGB术后1年累计体重减轻19.55 kg后，代谢特征和收缩压、舒张压均显著降低（p < 0.00001）。在LAGB前，病态肥胖患者NT-proBNP浓度显著高于正常体重对照组（341.15 +/- 127.78 fmol/mL vs. 161.68 +/- 75.78 fmol/mL, p < 0.00001）。减肥手术后，NT-proBNP浓度从341.15 +/- 127.78 fmol/mL显著下降至204.87 +/- 59.84 fmol/mL (p < 0.00001)，与正常体重者相比，NT-proBNP浓度仍显著升高（204.88 +/- 59.84 fmol/mL vs. 161.68 +/- 75.78 fmol/mL, p = 0.04）。讨论：本研究表明，在病态肥胖受试者中NT-proBNP水平较高，在腹腔镜可调节胃束带减肥期间NT-proBNP水平显著降低。在肥胖患者中，NT-proBNP可能作为一种常规筛查方法用于识别左心室肥厚和/或左心室功能障碍。
Objective: Aminoterminal pro-brain natriuretic peptide (NT-proBNP), like brain natriuretic peptide, might have diagnostic utility in detecting left ventricular hypertrophy and/or left ventricular dysfunction. The aim of the study was to investigate the relationship between morbid obesity and NT-proBNP and the effect of weight reduction on this parameter.Research Methods and Procedures: A total of 34 morbidly obese patients underwent laparoscopic adjustable gastric banding (LAGB). NT-proBNP levels were measured before and 12 months after the surgery.Results: Metabolic features and systolic and diastolic blood pressure were significantly decreased (p < 0.00001 for both) after a cumulative weight loss of 19.55 kg 1 year after LAGB. NT-proBNP concentration was significantly higher in morbidly obese patients before LAGB than in normal-weight control subjects (341.15 +/- 127.78 fmol/mL vs. 161.68 +/- 75.78 fmol/mL; p < 0.00001). After bariatric surgery, NT-proBNP concentration decreased significantly from 341.15 +/- 127.78 fmol/mL to 204.87 +/- 59.84 fmol/mL (p < 0.00,001) and remained statistically significantly elevated (204.88 +/- 59.84 fmol/mL vs. 161.68 +/- 75.78 fmol/mL; p = 0.04) compared with normal-weight subjects.Discussion: This investigation demonstrates higher levels of NT-proBNP in morbidly obese subjects and a significant decrease during weight loss after laparoscopic adjustable gastric banding. In obesity, NT-proBNP might be useful as a routine screening method for identifying left ventricular hypertrophy and/or left ventricular dysfunction.