Basic peptide protamine exerts antimicrobial activity against periodontopathic bacteria——Growth inhibition of periodontopathic bacteria by protamine
Basic peptide protamine exerts antimicrobial activity against periodontopathic bacteria——Growth inhibition of periodontopathic bacteria by protamine
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碱性肽鱼精蛋白对牙周病菌具有抗菌活性——鱼精蛋白对牙周病菌生长的抑制作用
DOI：
10.4236/jbise.2010.311138
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
M. Yoshinari
中科院分区：
文献类型：
--
作者：
T. Miura;K. Iohara;Tetsuo Kato;K. Ishihara;M. Yoshinari
研究了鱼精蛋白对牙周病原菌牙龈卟啉单胞菌、中间普雷沃氏菌和放线菌聚集菌的抗菌活性。测定了鱼精蛋白及其水解产物的最低抑菌浓度及其抑菌活性。鱼精蛋白抑制琼脂平板上所有牙周病细菌的生长。鱼精蛋白的MIC值为6.3 × 10-7 g L-1，对牙龈卟啉卟啉最有效。天然鱼精蛋白的抑菌效果高于其水解产物。ATP生物发光实验表明，鱼精蛋白对牙龈卟啉卟啉菌具有时间依赖性的杀菌活性。提示鱼精蛋白可能是预防牙龈卟啉单胞菌感染的候选肽。
Protamine was investigated for its antibacterial activity against the periodontal pathogens, Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans. We determined the minimum inhibitory concentrations of protamine and its hydrolysate and their bactericidal activity. Protamine inhibited the growth of all periodontopathic bacteria tested on agar plates. Protamine, which MIC was 6.3 × 10-7 g L-1, was most effective against P. gingivalis. The antibacterial effect of native protamine was higher than that of its hydrolysate. An ATP bioluminescence assay revealed that protamine showed bactericidal activity against P. gingivalis in a time-dependent manner. These results indicate that protamine could be candidate peptide for prevention of P. gingivalis infection.
影响因子：
4.9
作者：
Li, Yong Tao;Kwon, Young Min;Yang, Victor C.
通讯作者：
Yang, Victor C.
局限性青春期前牙周炎的患病率和微生物学。
影响因子：
--
作者：
Sweeney,EA;Alcoforado,GA;Nyman,S;Slots,J
通讯作者：
Slots,J