Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources
Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources
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DOI：
10.1016/j.cellimm.2010.06.006
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Lagneaux, Laurence
中科院分区：
文献类型：
--
作者：
Najar, Mehdi;Raicevic, Gordana;Lagneaux, Laurence
由于它们的免疫调节特性，脂肪组织（AT）和沃顿氏果冻（WJ）是bmm的有价值的替代品，可以作为MSCs的来源，用于治疗移植物抗宿主病。为了确保AT-和WJ-MSCs的效率，需要对它们的免疫调节功能进行表征，并与bmm进行比较。我们研究了AT-和WJ-MSC在不同刺激下调节淋巴细胞反应的能力，以及这种免疫调节的特异性——AT-和WJ-MSC对淋巴细胞反应表现出剂量依赖性的有效免疫抑制作用，这些作用包括防止淋巴细胞激活以及抑制t细胞增殖，而不管用于激活淋巴细胞的刺激是什么COX1/C0X2酶和PGE2 CD4（+）和CD8(+) t淋巴细胞同样被MSCs靶向，这表明免疫调节并不局限于特定的t细胞亚群(C) 2010 Elsevier Inc .版权所有
Due to their immunomodulatory properties, adipose tissue (AT) and Wharton's Jelly (WJ) constitute valuable alternatives to BM as sources of MSCs for managing graft-versus-host disease To ensure the efficiency of AT- and WJ-MSCs implies the characterization of their immunomodulatory functions in comparison to those of BM In this study, we investigated the capacity of AT- and WJ-MSCs to modulate lymphocyte ieactions in response to different stimuli as well as the specificity of this immunomodulanon AT- and WJ-MSC displayed potent immunosuppressive effects on lymphocyte responses in a dose-dependent manner These effects included the prevention of lymphocyte activation as well as the suppression of T-cell proliferation regardless of the stimuli used to activate lymphocytes These effects were mediated through the expression of COX1/C0X2 enzymes and by the production of PGE2 CD4(+) and CD8(+) T-lymphocytes were equally targeted by MSCs demonstrating that the immunomodulation was not restricted to a specific T-cell subpopulation (C) 2010 Elsevier Inc All rights reserved