Outpatient treatment of periocular infantile hemangiomas with oral propranolol
Outpatient treatment of periocular infantile hemangiomas with oral propranolol
复制标题
DOI：
10.1016/j.jaapos.2010.05.002
复制
发表时间：
2010-06-01
期刊：
影响因子：
1.6
通讯作者：
Haggstrom, Anita
中科院分区：
文献类型：
--
作者：
Haider, Kathryn M.;Plager, David A.;Haggstrom, Anita
背景技术最近报道普萘洛尔可用于治疗婴儿血管瘤。然而，关于剂量、持续时间和给药方法仍然存在许多问题。方法在这个回顾性、观察性病例系列中，所有患者都进行了完整的眼部检查，并发现有威胁视力的血管瘤。所有患者均进行基线心电图检查。门诊患者在 3 周至 12 个月大时开始口服普萘洛尔治疗。在 1-2 周内，剂量缓慢增加至每天 2 mg/kg。对治疗的反应被认为是“极好”（尺寸减小 > 50%）、“良好”（尺寸减小但尺寸减小）
BACKGROUND Propranolol has recently been reported to be useful in the treatment of infantile hemangiomas. However, there are still many questions regarding the dosage, duration, and method of delivery.METHODS In this retrospective, observational case series, all patients had complete eye examinations and were found to have vision-threatening hemangiomas. All patients had a baseline electrocardiogram. Outpatient, oral propranolol therapy was initiated between 3 weeks and 12 months of age. The dosage was slowly increased to 2 mg/kg daily over the course of 1-2 weeks. Response to therapy was deemed "excellent" (>50% reduction in size), "good" (decreased size but