Alternating Current Electrolysis for Organic Electrosynthesis: Trifluoromethylation of (Hetero)arenes
Alternating Current Electrolysis for Organic Electrosynthesis: Trifluoromethylation of (Hetero)arenes
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DOI：
10.1021/acs.orglett.0c01906
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发表时间：
2020-09-04
期刊：
影响因子：
5.2
通讯作者：
Luo, Long
中科院分区：
文献类型：
--
作者：
Rodrigo, Sachini;Um, Chanchamnan;Luo, Long
成对电解用于有机合成的反应范围有限，因为它通常与涉及短寿命中间体的反应不相容。我们使用交流电解(ACE)解决了这一限制。以(杂环)芳烃的三氟甲基化为模型反应，将产率从成对电解法的13%提高到ACE法的84%。为指导ACE的应用，合理设计反应参数提供了理论依据。
Paired electrolysis has a limited reaction scope for organic synthesis because it is often not compatible with reactions involving short-lived intermediates. We addressed this limitation using alternating current electrolysis (ACE). Using trifluoromethylation of (hetero)arenes as a model reaction, we showed that the yield was improved from 13% using paired electrolysis to 84% using ACE. We have also developed a theory for guiding the rational design of reaction parameters for future applications of ACE.