Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a
Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a
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DOI：
10.1182/blood-2004-12-4943
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发表时间：
2005-07-01
期刊：
影响因子：
20.3
通讯作者：
Irimura, T
中科院分区：
文献类型：
--
作者：
Sato, K;Imai, Y;Irimura, T
巨噬细胞半乳糖型C型凝集素（MGLs）最近被命名为CD 301，在小鼠中有2个同源物：MGL 1和MGL 2。MGL在巨噬细胞和未成熟树突细胞上表达。在野生型小鼠中观察到由蛋白抗原诱导的肉芽组织的持续存在，但在缺乏内源性巨噬细胞特异性半乳糖型钙型凝集素1（MGL 1）的小鼠中未观察到。抗MGL 1抗体抑制野生型小鼠的肉芽组织形成。大量的细胞，仅存在于MGL 1缺陷小鼠的袋中，不是髓系或淋巴系细胞，并且在给予白细胞介素1 α后数量显著下降。(IL-1α）注射到MGL 1缺陷小鼠的袋中。此外，通过该处理恢复肉芽组织，并且当注射MGL 1时，从MGL 1缺陷小鼠的袋中获得的细胞被掺入肉芽组织中。总之，在分泌IL-1 α的特定巨噬细胞亚群上表达的MGL 1被提出调节对肉芽组织形成至关重要的特定细胞相互作用。
Macrophage galactose-type C-type lectins (MGLs), which were recently named CD301, have 2 homologues in mice: MGL1 and MGL2. MGLs are expressed on macrophages and immature dendritic cells. The persistent presence of granulation tissue induced by a protein antigen was observed in wild-type mice but not in mice lacking an endogenous, macrophage-specific, galactose-type calcium-type lectin 1 (MGL1) in an air pouch model. The anti-MGL1 antibody suppressed the granulation tissue formation in wild-type mice. A large number of cells, present only in the pouch of MGL1-deficient mice, were not myeloid or lymphoid lineage cells and the number significantly declined after administration of interleukin 1 alpha. (IL-1 alpha) into the pouch of MGL1-deficient mice. Furthermore, granulation tissue was restored by this treatment and the cells obtained from the pouch of MGL1-deficient mice were incorporated into the granulation tissue when injected with Taken together, MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1 alpha was proposed to regulate specific cellular interactions crucial to granulation tissue formation.